If we have not eaten for a while or have to climb many stairs, the energy level of our cells drops and with it the level of insulin. The researchers from Bonn have now discovered that in the case of a low insulin level the FOXO transcription factor is activated. A transcription factor can switch genes on and off. FOXO switches genes for immune defence proteins on when energy is needed. These antimicrobial peptides (AMP) - not to be confused with antibodies - are subsequently jettisoned by the body's cells. They destroy possible pathogens by dissolving their cell walls. 'This happens every minute every day,' the director of studies Prof. Michael Hoch from the LIMES Institute explains. 'What is fascinating about this is that a function of the immune system directly depends on how much and what we eat.' In situations of hunger which mean stress for the body cells, the body releases antimicrobial peptides as a precaution in order to protect itself. 'The barrier between body and outside world is apparently fortified in a potentially dangerous situation in which we have too little energy,' Professor Hoch presumes.
Ancient defence mechanism helps us to get old?
FOXO and the antimicrobial peptide genes which it switches on occur in almost all groups of animals. That is why the researchers believe that the direct link between the food supply and the immunological defence probably developed during the early stage of evolution of metazoan organisms.
The research of the Bonn biologists could also be clinically relevant. For a number of common diseases such as type II diabetes or obesity (adiposity) are the result of an increased intake of calories. Furthermore, such diseases are accompanied by increased inflammation of the barrier tissue, a disturbed immune system and an overall reduced life span. 'Our results present new starting points for understanding of these diseases,' Professor Joachim Schultze from the LIMES Institute, who also is involved in the research project, says.
The scientists at LIMES will concentrate next on the relationship between calorie intake and life span. Examinations of nematodes, fruit flies and mice have shown that a reduced calorie intake can increase life span. Professor Hoch says: 'We now want to find out whether this is due to an foxo-dependent improvement of the barrier functions of the natural immune system.'
Source: University of Bonn