Findings of the study also showed that the RYGB could significantly increase the post surgical expression of PDX-1 and promotes regeneration of -Cells in GK rats. GK rat is a non-obese genetically diabetic animal model commonly used to simulate human diabetes in the laboratory. This study was conducted using three groups of GK rats, RYGB surgery groups and two control groups. Post-surgically, each group was subjected to quantitative analysis of PDX-1 and pancreatic -cells and result showed significant increase in the expression of PDX-1 as well as regeneration of -cells in the RYGB surgery group compared to control groups. These findings provided concrete evidence to explain that the increased expression of the PDX-1 and regeneration -cells are the associated mechanisms of RYGB surgery to treat T2DM. This study could be a turning point and takes diabetic related studies to a new path to develop a curative treatment for diabetes.

Source: World Journal of Gastroenterology