Long-term results further reinforce the excellent clinical outcomes, with XIENCE V demonstrating an 88 percent reduction in the risk of cardiac death (0.5 percent for XIENCE V vs. 4.2 percent for TAXUS,>

Additionally, in the SPIRIT V (five) international, single-arm study of 2,663 patients in Europe and Asia-Pacific, XIENCE V demonstrated a very low 1.8 percent rate of target lesion revascularization (TLR), a 0.7 percent rate of definite/probable stent thrombosis and a 5.1 percent rate of MACE at one year, in a diverse, "real world" population of patients and lesion types. For the SPIRIT V trial, MACE is defined as a composite of cardiac death, heart attack (myocardial infarction not clearly attributed to a non-target vessel), or TLR.

Data from the company's SPIRIT IV trial comparing XIENCE V to TAXUS will be presented at the Transcatheter Cardiovascular Therapeutics annual meeting in September 2009. With 3,690 patients, the SPIRIT IV trial is one of the largest head-to-head randomized clinical trials between two drug eluting stents and includes more than 1,000 patients with diabetes. Across the SPIRIT family of trials, Abbott plans to study approximately 22,000 patients treated with an everolimus eluting stent.

XIENCE PRIME is the latest innovation from Abbott's robust vascular research program, which includes clinical trials in coronary artery disease and peripheral artery disease. Key products in the vascular pipeline include: the MULTI-LINK 8(TM) Coronary Stent System, a next-generation frontline balloon dilatation catheter, and a fully bioabsorbable drug eluting coronary device. All products are in development and are not available for sale.

Source: abbott