"Future studies, particularly long-term, prospective randomized clinical trials will be needed to conclusively demonstrate small to moderate harm," said Herman.

Other researchers working on the study include: Doris Bilik, Laura McEwen, Morton Brown, Catherine Kim, Keiko Asao, Victoria Hsiao and Pearl Lee of the University of Michigan in Ann Arbor; Nathan Pomeroy of the Center for Diabetes and Endocrinology in Grand Rapids, Mich.; Jesse Crosson of UMDNJ-Robert Wood Johnson Medical School in Somerset, N.J.; O. Kenrik Duru of the University of California in Los Angeles; Assiamira Ferrara, Andrew Karter and Joe Selby of Kaiser Permanente in Oakland, Calif.; and David Marrero and Usha Subramanian of Indiana University School of Medicine in Indianapolis.

The article, "Thiazolidinediones and Fractures: Evidence from Translating Research into Action for Diabetes (TRIAD)," will appear in the October 2010 issue of JCEM.

Source The Endocrine Society