JDRF-Funded Studies These landmark studies combine to provide the largest body of Personal CGM data in children, adolescents, and adults. The largest of these studies examined 322 patients (ages 8-72) with poor glycemic control (A1C levels 7 percent to 10 percent). Results at six months3 showed that the use of glucose sensors varied between the age groups, with the most significant results occurring in adults who used Personal CGM regularly. At 12 months,4 nearly 90 percent of these Personal CGM users continued using the therapy and A1C reductions were sustained despite less intensive follow-up. Study results5 of patients with good glycemic control (A1C levels <7 percent), demonstrated improved glucose control with less hypoglycemia when using Personal CGM.

REAL Trend Study (132 patients, Ages 2-65): This study investigated whether subjects using MDI could benefit from Personal CGM at insulin pump initiation. Results showed that insulin pumps (both conventional and with Personal CGM) result in significant A1C improvement compared to MDI therapy. The greatest A1C reduction occurred when using Personal CGM more than 70 percent of the time. Study subjects using Personal CGM achieved nearly a full percentage point in A1C reduction without increasing hypoglycemia.

EURYTHMICS Study (83 patients, Ages 18-65): This study demonstrated the additional benefits of moving type 1 patients with poor glycemic control (A1C levels ?‰?8.2 percent) from MDI directly to an insulin pump with Personal CGM. The Personal CGM group experienced an A1C reduction >1 percent and more than one-third of these patients achieved A1C levels of 7 percent or less without increasing hypoglycemia. No patients in the MDI group achieved this goal.

ONSET Trial (160 patients, Ages 1-16): This trial explored whether children newly diagnosed with diabetes can benefit from using an insulin pump with Personal CGM at the onset of their disease. Twelve month data presented orally at the 2009 International Diabetes Federation found that insulin pump therapy at diabetes onset results in lower A1C values compared to historical controls (using insulin injections during the first 12 months after diagnosis). Children using Personal CGM at least once a week experienced significantly lower A1C values, fewer episodes of severe hypoglycemia, and had significantly less C-peptide loss.

Source: Medtronic Diabetes