Many inflammatory and autoimmune diseases are chronic and affect a large majority of people. Moreover, there is an inflammatory component to many common diseases, such as Alzheimer's, Parkinson's, RA, AA, MS, type II diabetes and cancers. The vaccine discovered by the researchers boosts special cells of the immune system, called NKT cells. NKT cells are a type of T cell that exert profound and diverse regulatory effects in disease, from autoimmunity to responses to pathogens and cancer. For over two decades since their discovery NKT cells have traditionally been considered to be activated by lipid antigens presented by CD1 molecules. However, Professor Issazadeh-Navikas' group was able to show for the first time the ability of a self peptide to activate NKT cells to suppress many tissue-specific inflammatory conditions including experimental autoimmune diseases. This highly significant and novel finding offers a new perspective on the ways in which the body combats inflammation in both health and disease. In addition, the researchers identified the activation requirements and signaling pathway through which they exert their function.

Professor Issazadeh-Navikas highlighted, "Our data offer a novel perspective on the physiological role of these cells in maintenance of tissue homeostasis and reduction of inflammation".

The findings significantly advance the fields of autoimmunity, antigen presentation, and NKT cells. They provide mechanistic insight into the biology of these cells and their roles in disease and point the way to therapies to treat many of the common conditions of mankind.

Source: University of Copenhagen